Drug interactions
Flurbiprofen + Hydrochlorothiazide-olmesartan
Severity: Major
Flurbiprofen and Hydrochlorothiazide-olmesartan: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can reduce the blood pressure lowering effect of olmesartan and hydrochlorothiazide. The NSAID, ARB and diuretic combination may cause acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
What this interaction means in plain words
Flurbiprofen and Hydrochlorothiazide-olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Flurbiprofen belongs to Musculoskeletal; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, compounding ARB effects on glomerular filtration.
What to do
Avoid prolonged NSAID use, maintain hydration, and monitor blood pressure, creatinine and potassium after starting.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as major. Flurbiprofen and Hydrochlorothiazide-olmesartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flurbiprofen can reduce the blood pressure lowering effect of olmesartan and hydrochlorothiazide. The NSAID, ARB and diuretic combination may cause acute kidney injury and hyperkalemia, particularly in older or volume-depleted patients.
How serious is the interaction between Flurbiprofen and Hydrochlorothiazide-olmesartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged NSAID use, maintain hydration, and monitor blood pressure, creatinine and potassium after starting.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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