Drug interactions
Flurbiprofen + Hydrocortisone
Severity: Moderate
Flurbiprofen and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using a corticosteroid with an NSAID increases the risk of gastrointestinal ulcers and bleeding compared with either drug alone. Older patients and those on prolonged or high-dose therapy are most affected.
What this interaction means in plain words
Flurbiprofen and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Hydrocortisone belongs to Endocrine.
Why it happens
Additive gastrointestinal mucosal damage from NSAID prostaglandin inhibition and corticosteroid impairment of mucosal healing.
What to do
Use the lowest effective doses for the shortest time and add a proton pump inhibitor for patients at elevated GI risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Hydrocortisone?
MediHelp rates the interaction as moderate. Flurbiprofen and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using a corticosteroid with an NSAID increases the risk of gastrointestinal ulcers and bleeding compared with either drug alone. Older patients and those on prolonged or high-dose therapy are most affected.
How serious is the interaction between Flurbiprofen and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and add a proton pump inhibitor for patients at elevated GI risk.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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