Drug interactions
Flurbiprofen + Metronidazole
Severity: Minor
Flurbiprofen and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole may weakly inhibit CYP2C9 and could raise flurbiprofen levels, but a clinically meaningful effect has not been well demonstrated.
What this interaction means in plain words
Flurbiprofen and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Flurbiprofen belongs to Musculoskeletal; Metronidazole belongs to Anti Parasitic.
Why it happens
Possible weak inhibition of CYP2C9-mediated metabolism.
What to do
No routine adjustment needed; monitor for NSAID adverse effects during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Flurbiprofen with Metronidazole?
MediHelp rates the interaction as minor. Flurbiprofen and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole may weakly inhibit CYP2C9 and could raise flurbiprofen levels, but a clinically meaningful effect has not been well demonstrated.
How serious is the interaction between Flurbiprofen and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed; monitor for NSAID adverse effects during prolonged co-therapy.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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