Drug interactions
Flurbiprofen + Miconazole vaginal
Severity: Minor
Flurbiprofen and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic absorption of vaginal miconazole is low, though it can inhibit CYP2C9 and has caused warfarin interactions. A meaningful rise in flurbiprofen levels is unlikely.
What this interaction means in plain words
Flurbiprofen and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Potential CYP2C9 inhibition by absorbed miconazole, limited by low systemic absorption.
What to do
No action is usually needed; be alert for NSAID adverse effects if prolonged or high-dose miconazole is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Miconazole vaginal?
MediHelp rates the interaction as minor. Flurbiprofen and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Systemic absorption of vaginal miconazole is low, though it can inhibit CYP2C9 and has caused warfarin interactions. A meaningful rise in flurbiprofen levels is unlikely.
How serious is the interaction between Flurbiprofen and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed; be alert for NSAID adverse effects if prolonged or high-dose miconazole is used.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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