Drug interactions
Flurbiprofen + Parecoxib
Severity: Major
Flurbiprofen and Parecoxib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a nonselective NSAID with parecoxib, a COX-2 inhibitor prodrug, duplicates therapy and increases the risk of gastrointestinal bleeding and ulceration, renal impairment, hyperkalemia and cardiovascular events without added benefit.
What this interaction means in plain words
Flurbiprofen and Parecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive cyclooxygenase inhibition with duplicated effects on gastric mucosa, renal prostaglandins and platelet function.
What to do
Avoid concurrent use and choose a single NSAID at the lowest effective dose; if overlap is unavoidable, monitor renal function, potassium and for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Parecoxib?
MediHelp rates the interaction as major. Flurbiprofen and Parecoxib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a nonselective NSAID with parecoxib, a COX-2 inhibitor prodrug, duplicates therapy and increases the risk of gastrointestinal bleeding and ulceration, renal impairment, hyperkalemia and cardiovascular events without added benefit.
How serious is the interaction between Flurbiprofen and Parecoxib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose a single NSAID at the lowest effective dose; if overlap is unavoidable, monitor renal function, potassium and for bleeding.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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