Drug interactions
Flurbiprofen + Pentobarbital
Severity: Minor
Flurbiprofen and Pentobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital may lower flurbiprofen exposure through enzyme induction. Any loss of analgesic effect is likely small.
What this interaction means in plain words
Flurbiprofen and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of hepatic CYP2C9 may increase flurbiprofen metabolism.
What to do
No routine change is needed; reassess flurbiprofen efficacy if barbiturate therapy is prolonged.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Pentobarbital?
MediHelp rates the interaction as minor. Flurbiprofen and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentobarbital may lower flurbiprofen exposure through enzyme induction. Any loss of analgesic effect is likely small.
How serious is the interaction between Flurbiprofen and Pentobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; reassess flurbiprofen efficacy if barbiturate therapy is prolonged.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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