Drug interactions
Flurbiprofen + Perindopril
Severity: Moderate
Flurbiprofen and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can reduce the antihypertensive effect of perindopril and may worsen kidney function, particularly in elderly, dehydrated or renally impaired patients. Hyperkalemia risk is also increased.
What this interaction means in plain words
Flurbiprofen and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Perindopril belongs to Cardiovascular.
Why it happens
NSAID inhibition of cyclooxygenase reduces renal vasodilatory prostaglandins and sodium excretion, opposing ACE inhibitor effects and lowering glomerular filtration.
What to do
Prefer a non-NSAID analgesic; if the NSAID is needed, ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting and periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Flurbiprofen with Perindopril?
MediHelp rates the interaction as moderate. Flurbiprofen and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen can reduce the antihypertensive effect of perindopril and may worsen kidney function, particularly in elderly, dehydrated or renally impaired patients. Hyperkalemia risk is also increased.
How serious is the interaction between Flurbiprofen and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic; if the NSAID is needed, ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting and periodically.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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