Drug interactions
Flurbiprofen + Phenindione
Severity: Major
Flurbiprofen and Phenindione: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenindione is a vitamin K antagonist, and flurbiprofen adds antiplatelet effects and gastrointestinal mucosal injury. The combination markedly increases bleeding risk, and NSAIDs may also displace oral anticoagulants from protein binding.
What this interaction means in plain words
Flurbiprofen and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive hemostatic impairment with NSAID antiplatelet action and mucosal injury, plus possible protein-binding displacement.
What to do
Avoid the combination and use paracetamol for analgesia; if unavoidable, monitor INR and bleeding closely and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Phenindione?
MediHelp rates the interaction as major. Flurbiprofen and Phenindione can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenindione is a vitamin K antagonist, and flurbiprofen adds antiplatelet effects and gastrointestinal mucosal injury. The combination markedly increases bleeding risk, and NSAIDs may also displace oral anticoagulants from protein binding.
How serious is the interaction between Flurbiprofen and Phenindione?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use paracetamol for analgesia; if unavoidable, monitor INR and bleeding closely and consider gastroprotection.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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