Drug interactions
Flurbiprofen + Phenobarbital
Severity: Minor
Flurbiprofen and Phenobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic phenobarbital may reduce flurbiprofen concentrations through enzyme induction. This could modestly weaken its analgesic or anti-inflammatory effect.
What this interaction means in plain words
Flurbiprofen and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenobarbital induction of hepatic CYP2C9 increases flurbiprofen metabolism.
What to do
Reassess flurbiprofen response during long-term phenobarbital use and adjust the dose or choose another analgesic if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Phenobarbital?
MediHelp rates the interaction as minor. Flurbiprofen and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic phenobarbital may reduce flurbiprofen concentrations through enzyme induction. This could modestly weaken its analgesic or anti-inflammatory effect.
How serious is the interaction between Flurbiprofen and Phenobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reassess flurbiprofen response during long-term phenobarbital use and adjust the dose or choose another analgesic if efficacy is lost.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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