Drug interactions
Flurbiprofen + Pindolol
Severity: Moderate
Flurbiprofen and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can reduce the antihypertensive effect of pindolol, particularly with continued use beyond a week or so. Blood pressure may rise and fluid retention may occur.
What this interaction means in plain words
Flurbiprofen and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal and vascular prostaglandins leads to sodium and water retention and opposes beta-blocker effect.
What to do
Check blood pressure regularly during combined use and adjust antihypertensive therapy as needed; limit NSAID dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Pindolol?
MediHelp rates the interaction as moderate. Flurbiprofen and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurbiprofen can reduce the antihypertensive effect of pindolol, particularly with continued use beyond a week or so. Blood pressure may rise and fluid retention may occur.
How serious is the interaction between Flurbiprofen and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure regularly during combined use and adjust antihypertensive therapy as needed; limit NSAID dose and duration.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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