Drug interactions
Flurbiprofen + Reteplase
Severity: Major
Flurbiprofen and Reteplase: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reteplase is a thrombolytic that carries a substantial bleeding risk. NSAIDs inhibit platelet function and can injure the gastric mucosa, which may further increase the likelihood of serious hemorrhage.
What this interaction means in plain words
Flurbiprofen and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive impairment of hemostasis: fibrinolysis from reteplase plus NSAID platelet inhibition and mucosal injury.
What to do
Avoid starting or continuing NSAIDs around thrombolysis unless essential; monitor closely for bleeding at puncture sites, gastrointestinal tract and intracranially.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Reteplase?
MediHelp rates the interaction as major. Flurbiprofen and Reteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reteplase is a thrombolytic that carries a substantial bleeding risk. NSAIDs inhibit platelet function and can injure the gastric mucosa, which may further increase the likelihood of serious hemorrhage.
How serious is the interaction between Flurbiprofen and Reteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting or continuing NSAIDs around thrombolysis unless essential; monitor closely for bleeding at puncture sites, gastrointestinal tract and intracranially.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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