Drug interactions
Flurbiprofen + Rivastigmine
Severity: Moderate
Flurbiprofen and Rivastigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholinesterase inhibitors increase gastric acid secretion, which may add to NSAID-related gastric irritation and raise the risk of ulcers and GI bleeding.
What this interaction means in plain words
Flurbiprofen and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Rivastigmine belongs to Central Nervous System.
Why it happens
Enhanced cholinergic stimulation of gastric acid secretion combines with NSAID-induced loss of mucosal prostaglandin protection.
What to do
Monitor for symptoms of GI bleeding or dyspepsia and consider gastroprotection with a proton pump inhibitor in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Rivastigmine
Frequently asked questions
Can I take Flurbiprofen with Rivastigmine?
MediHelp rates the interaction as moderate. Flurbiprofen and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholinesterase inhibitors increase gastric acid secretion, which may add to NSAID-related gastric irritation and raise the risk of ulcers and GI bleeding.
How serious is the interaction between Flurbiprofen and Rivastigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for symptoms of GI bleeding or dyspepsia and consider gastroprotection with a proton pump inhibitor in high-risk patients.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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