Drug interactions
Flurbiprofen + Salicylates
Severity: Moderate
Flurbiprofen and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining flurbiprofen with other salicylates duplicates NSAID-type effects, increasing the risk of gastrointestinal irritation and bleeding, renal impairment and hyperkalemia. Salicylates may also alter NSAID protein binding and clearance.
What this interaction means in plain words
Flurbiprofen and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cyclooxygenase inhibition affecting gastric mucosa, platelets and renal prostaglandins.
What to do
Avoid routine co-use and choose a single agent; if combined, monitor for gastrointestinal bleeding and check renal function and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Flurbiprofen and Salicylates, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Salicylates?
MediHelp rates the interaction as moderate. Flurbiprofen and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining flurbiprofen with other salicylates duplicates NSAID-type effects, increasing the risk of gastrointestinal irritation and bleeding, renal impairment and hyperkalemia. Salicylates may also alter NSAID protein binding and clearance.
How serious is the interaction between Flurbiprofen and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine co-use and choose a single agent; if combined, monitor for gastrointestinal bleeding and check renal function and potassium.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
