Drug interactions
Flurbiprofen + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Flurbiprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This bowel preparation causes fluid loss and electrolyte shifts. NSAIDs reduce renal perfusion, so dehydration with an NSAID can raise the risk of acute kidney injury.
What this interaction means in plain words
Flurbiprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bowel-prep-induced volume depletion combined with NSAID inhibition of renal prostaglandins impairs renal perfusion.
What to do
Withhold flurbiprofen during the bowel preparation period where feasible and ensure adequate oral fluid intake; check renal function and electrolytes in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Flurbiprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This bowel preparation causes fluid loss and electrolyte shifts. NSAIDs reduce renal perfusion, so dehydration with an NSAID can raise the risk of acute kidney injury.
How serious is the interaction between Flurbiprofen and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold flurbiprofen during the bowel preparation period where feasible and ensure adequate oral fluid intake; check renal function and electrolytes in high-risk patients.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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