Drug interactions
Flurbiprofen + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Moderate
Flurbiprofen and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can promote water retention and impair renal function, and bowel preparations can cause fluid loss and electrolyte shifts including hyponatremia. Together they may raise the risk of electrolyte disturbance and kidney injury.
What this interaction means in plain words
Flurbiprofen and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID-related reduction in free water excretion and renal perfusion combined with bowel-prep fluid and electrolyte shifts.
What to do
Hold flurbiprofen during bowel preparation where possible and ensure adequate hydration; check sodium and renal function in elderly or high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as moderate. Flurbiprofen and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can promote water retention and impair renal function, and bowel preparations can cause fluid loss and electrolyte shifts including hyponatremia. Together they may raise the risk of electrolyte disturbance and kidney injury.
How serious is the interaction between Flurbiprofen and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold flurbiprofen during bowel preparation where possible and ensure adequate hydration; check sodium and renal function in elderly or high-risk patients.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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