Drug interactions
Flurbiprofen + Sulfamethoxazole
Severity: Moderate
Flurbiprofen and Sulfamethoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole inhibits CYP2C9 and may raise flurbiprofen levels. NSAIDs and trimethoprim-sulfamethoxazole may also both affect renal function and potassium.
What this interaction means in plain words
Flurbiprofen and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sulfamethoxazole inhibition of CYP2C9-mediated flurbiprofen metabolism, with additive renal effects.
What to do
Monitor renal function and potassium, especially in older patients or those with kidney disease, and use the lowest effective flurbiprofen dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Sulfamethoxazole?
MediHelp rates the interaction as moderate. Flurbiprofen and Sulfamethoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfamethoxazole inhibits CYP2C9 and may raise flurbiprofen levels. NSAIDs and trimethoprim-sulfamethoxazole may also both affect renal function and potassium.
How serious is the interaction between Flurbiprofen and Sulfamethoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and potassium, especially in older patients or those with kidney disease, and use the lowest effective flurbiprofen dose.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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