Drug interactions
Flurbiprofen + Sulfasalazine
Severity: Minor
Flurbiprofen and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen may add to gastrointestinal irritation and, through platelet inhibition, bleeding risk, while sulfasalazine can cause blood dyscrasias. NSAIDs may also reduce renal function. The clinical effect is usually modest but can matter in older or high-risk patients.
What this interaction means in plain words
Flurbiprofen and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effects on GI mucosa and hemostasis; no major pharmacokinetic interaction is established.
What to do
Monitor for GI bleeding symptoms, and check CBC and renal function periodically during long-term combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Sulfasalazine?
MediHelp rates the interaction as minor. Flurbiprofen and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Flurbiprofen may add to gastrointestinal irritation and, through platelet inhibition, bleeding risk, while sulfasalazine can cause blood dyscrasias. NSAIDs may also reduce renal function. The clinical effect is usually modest but can matter in older or high-risk patients.
How serious is the interaction between Flurbiprofen and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding symptoms, and check CBC and renal function periodically during long-term combined use.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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