Drug interactions
Flurbiprofen + Venlafaxine
Severity: Moderate
Flurbiprofen and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine reduces platelet serotonin uptake and impairs platelet aggregation, and flurbiprofen adds antiplatelet and mucosal-damaging effects. The combination increases the risk of bleeding, especially upper gastrointestinal bleeding.
What this interaction means in plain words
Flurbiprofen and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Flurbiprofen belongs to Musculoskeletal; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive platelet dysfunction from serotonin reuptake inhibition and COX-1 inhibition, plus NSAID gastric mucosal injury.
What to do
Monitor for signs of bleeding and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Flurbiprofen with Venlafaxine?
MediHelp rates the interaction as moderate. Flurbiprofen and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine reduces platelet serotonin uptake and impairs platelet aggregation, and flurbiprofen adds antiplatelet and mucosal-damaging effects. The combination increases the risk of bleeding, especially upper gastrointestinal bleeding.
How serious is the interaction between Flurbiprofen and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider gastroprotection with a proton pump inhibitor in higher-risk patients. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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