Drug interactions
Flurbiprofen + Willow bark
Severity: Moderate
Flurbiprofen and Willow bark: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylic acid, so it adds salicylate exposure to an NSAID. This may increase the risk of GI irritation, bleeding and renal effects.
What this interaction means in plain words
Flurbiprofen and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effects through cyclooxygenase inhibition by salicylates and the NSAID.
What to do
Avoid concurrent use where possible and counsel patients to report GI bleeding or kidney symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Flurbiprofen with Willow bark?
MediHelp rates the interaction as moderate. Flurbiprofen and Willow bark can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Willow bark contains salicin, which is converted to salicylic acid, so it adds salicylate exposure to an NSAID. This may increase the risk of GI irritation, bleeding and renal effects.
How serious is the interaction between Flurbiprofen and Willow bark?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and counsel patients to report GI bleeding or kidney symptoms.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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