Drug interactions
Fluticasone furoate + Istradefylline
Severity: Minor
Fluticasone furoate and Istradefylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg/day weakly inhibits CYP3A4 and may modestly raise fluticasone furoate exposure. At 20 mg/day this effect was not observed, so significance is low.
What this interaction means in plain words
Fluticasone furoate and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Istradefylline at higher doses inhibits CYP3A4, decreasing fluticasone metabolism.
What to do
Usually no change is needed; watch for corticosteroid adverse effects if istradefylline 40 mg/day is used with long-term fluticasone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Istradefylline
Frequently asked questions
Can I take Fluticasone furoate with Istradefylline?
MediHelp rates the interaction as minor. Fluticasone furoate and Istradefylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at 40 mg/day weakly inhibits CYP3A4 and may modestly raise fluticasone furoate exposure. At 20 mg/day this effect was not observed, so significance is low.
How serious is the interaction between Fluticasone furoate and Istradefylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usually no change is needed; watch for corticosteroid adverse effects if istradefylline 40 mg/day is used with long-term fluticasone.
What other medicines interact with Istradefylline?
MediHelp also lists interactions of Istradefylline with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Istradefylline page.
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