Drug interactions
Fluticasone furoate + Larotrectinib
Severity: Minor
Fluticasone furoate and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and weak inhibitor, so it may slightly raise fluticasone furoate levels. Clinical impact is probably minimal at inhaled or nasal doses.
What this interaction means in plain words
Fluticasone furoate and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 inhibition by larotrectinib.
What to do
No routine adjustment is needed; monitor for corticosteroid adverse effects with prolonged treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Larotrectinib
Frequently asked questions
Can I take Fluticasone furoate with Larotrectinib?
MediHelp rates the interaction as minor. Fluticasone furoate and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and weak inhibitor, so it may slightly raise fluticasone furoate levels. Clinical impact is probably minimal at inhaled or nasal doses.
How serious is the interaction between Fluticasone furoate and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for corticosteroid adverse effects with prolonged treatment.
What other medicines interact with Larotrectinib?
MediHelp also lists interactions of Larotrectinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Larotrectinib page.
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