Drug interactions
Fluticasone furoate + Nelfinavir
Severity: Moderate
Fluticasone furoate and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nelfinavir inhibits CYP3A4 and may increase systemic fluticasone furoate exposure, raising the risk of Cushingoid effects and adrenal suppression with prolonged use.
What this interaction means in plain words
Fluticasone furoate and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nelfinavir inhibits CYP3A4-mediated fluticasone metabolism.
What to do
Monitor for Cushingoid features and adrenal suppression, or switch to beclomethasone for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone furoate with Nelfinavir?
MediHelp rates the interaction as moderate. Fluticasone furoate and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nelfinavir inhibits CYP3A4 and may increase systemic fluticasone furoate exposure, raising the risk of Cushingoid effects and adrenal suppression with prolonged use.
How serious is the interaction between Fluticasone furoate and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features and adrenal suppression, or switch to beclomethasone for long-term therapy.
What other medicines interact with Nelfinavir?
MediHelp also lists interactions of Nelfinavir with, for example, Alfuzosin, Avanafil, Dronedarone. The full list is on the Nelfinavir page.
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