Drug interactions
Fluticasone furoate + Primidone
Severity: Minor
Fluticasone furoate and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolised to phenobarbital, a CYP3A4 inducer, and may lower fluticasone furoate exposure. Clinical impact with inhaled or intranasal use is expected to be small.
What this interaction means in plain words
Fluticasone furoate and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Primidone and its metabolite phenobarbital induce CYP3A4, increasing fluticasone clearance.
What to do
Monitor symptom control and increase the corticosteroid dose if response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Fluticasone furoate with Primidone?
MediHelp rates the interaction as minor. Fluticasone furoate and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone is metabolised to phenobarbital, a CYP3A4 inducer, and may lower fluticasone furoate exposure. Clinical impact with inhaled or intranasal use is expected to be small.
How serious is the interaction between Fluticasone furoate and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and increase the corticosteroid dose if response is reduced.
What other medicines interact with Primidone?
MediHelp also lists interactions of Primidone with, for example, Lorlatinib, Lurasidone, Ranolazine. The full list is on the Primidone page.
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