Drug interactions
Fluticasone furoate + Rifabutin
Severity: Minor
Fluticasone furoate and Rifabutin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may lower fluticasone furoate exposure. This could lead to reduced control of the underlying respiratory or allergic condition.
What this interaction means in plain words
Fluticasone furoate and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 by rifabutin enhances fluticasone furoate metabolism.
What to do
Monitor symptom control and adjust therapy if the response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone furoate and Rifabutin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Fluticasone furoate with Rifabutin?
MediHelp rates the interaction as minor. Fluticasone furoate and Rifabutin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rifabutin induces CYP3A4 and may lower fluticasone furoate exposure. This could lead to reduced control of the underlying respiratory or allergic condition.
How serious is the interaction between Fluticasone furoate and Rifabutin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and adjust therapy if the response is inadequate.
What other medicines interact with Rifabutin?
MediHelp also lists interactions of Rifabutin with, for example, Cabotegravir, Lorlatinib, Voriconazole. The full list is on the Rifabutin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
