Drug interactions
Fluticasone-salmeterol + Levalbuterol
Severity: Moderate
Fluticasone-salmeterol and Levalbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol and levalbuterol are both beta2-agonists, so combined use can cause additive tachycardia, tremor, palpitations and hypokalemia. Regular use of a long-acting agent already provides bronchodilation, so frequent rescue use signals poor control.
What this interaction means in plain words
Fluticasone-salmeterol and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive beta2-adrenergic stimulation including beta2-mediated potassium shift.
What to do
Use levalbuterol only as needed for rescue and monitor heart rate and potassium if use is frequent. Reassess therapy if rescue use increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone-salmeterol and Levalbuterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Levalbuterol?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Levalbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salmeterol and levalbuterol are both beta2-agonists, so combined use can cause additive tachycardia, tremor, palpitations and hypokalemia. Regular use of a long-acting agent already provides bronchodilation, so frequent rescue use signals poor control.
How serious is the interaction between Fluticasone-salmeterol and Levalbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use levalbuterol only as needed for rescue and monitor heart rate and potassium if use is frequent. Reassess therapy if rescue use increases.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
