Drug interactions
Fluticasone-salmeterol + Lofepramine
Severity: Moderate
Fluticasone-salmeterol and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as lofepramine may potentiate cardiovascular effects of beta-agonists like salmeterol. This can lead to tachycardia, arrhythmia and QT prolongation.
What this interaction means in plain words
Fluticasone-salmeterol and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tricyclic noradrenaline reuptake inhibition and additive QT effects enhancing beta-agonist cardiovascular response.
What to do
Monitor heart rate and ECG, especially in patients with cardiac disease or electrolyte disturbance. Consider alternatives if palpitations or QTc prolongation occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Lofepramine?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants such as lofepramine may potentiate cardiovascular effects of beta-agonists like salmeterol. This can lead to tachycardia, arrhythmia and QT prolongation.
How serious is the interaction between Fluticasone-salmeterol and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, especially in patients with cardiac disease or electrolyte disturbance. Consider alternatives if palpitations or QTc prolongation occur.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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