Drug interactions
Fluticasone-salmeterol + Loxapine inhaled
Severity: Moderate
Fluticasone-salmeterol and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine can cause bronchospasm, particularly in patients with asthma or COPD, which is the population likely to use salmeterol. Patients with active airway disease are excluded from its use, and a bronchodilator pretreatment is required by labeling.
What this interaction means in plain words
Fluticasone-salmeterol and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhaled loxapine can provoke bronchospasm; salmeterol use indicates underlying airway disease that raises this risk.
What to do
Avoid inhaled loxapine in patients with active asthma or COPD; if used, give a short-acting bronchodilator beforehand and monitor respiratory status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Loxapine inhaled?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine can cause bronchospasm, particularly in patients with asthma or COPD, which is the population likely to use salmeterol. Patients with active airway disease are excluded from its use, and a bronchodilator pretreatment is required by labeling.
How serious is the interaction between Fluticasone-salmeterol and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid inhaled loxapine in patients with active asthma or COPD; if used, give a short-acting bronchodilator beforehand and monitor respiratory status.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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