Drug interactions
Fluticasone-salmeterol + Methyclothiazide
Severity: Moderate
Fluticasone-salmeterol and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both the beta-2 agonist component and the thiazide diuretic can lower serum potassium. Together they may produce clinically relevant hypokalemia, which raises the risk of arrhythmias, particularly in patients with heart disease or on other QT-prolonging drugs.
What this interaction means in plain words
Fluticasone-salmeterol and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia: salmeterol shifts potassium into cells via beta-2 stimulation while the thiazide increases renal potassium loss.
What to do
Check serum potassium and magnesium at baseline and periodically, especially with high or frequent salmeterol dosing. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Methyclothiazide?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both the beta-2 agonist component and the thiazide diuretic can lower serum potassium. Together they may produce clinically relevant hypokalemia, which raises the risk of arrhythmias, particularly in patients with heart disease or on other QT-prolonging drugs.
How serious is the interaction between Fluticasone-salmeterol and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium at baseline and periodically, especially with high or frequent salmeterol dosing. Replace potassium as needed.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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