Drug interactions
Fluticasone-salmeterol + Methylenedioxymethamphetamine
Severity: Moderate
Fluticasone-salmeterol and Methylenedioxymethamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA is a strong sympathomimetic and salmeterol is a beta-2 agonist with cardiovascular effects. Combined use may further raise heart rate and blood pressure and may provoke palpitations or arrhythmias.
What this interaction means in plain words
Fluticasone-salmeterol and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation: MDMA releases catecholamines and serotonin while salmeterol directly stimulates beta-adrenergic receptors.
What to do
Advise patients to avoid MDMA. If exposure has occurred, monitor heart rate, blood pressure and ECG and treat tachyarrhythmia or hypertension symptomatically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Methylenedioxymethamphetamine?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Methylenedioxymethamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MDMA is a strong sympathomimetic and salmeterol is a beta-2 agonist with cardiovascular effects. Combined use may further raise heart rate and blood pressure and may provoke palpitations or arrhythmias.
How serious is the interaction between Fluticasone-salmeterol and Methylenedioxymethamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid MDMA. If exposure has occurred, monitor heart rate, blood pressure and ECG and treat tachyarrhythmia or hypertension symptomatically.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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