Drug interactions
Fluticasone-salmeterol + Moxonidine
Severity: Minor
Fluticasone-salmeterol and Moxonidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that can cause drowsiness and lower blood pressure, whereas salmeterol can cause tachycardia and stimulation. The net effect is unpredictable and usually small.
What this interaction means in plain words
Fluticasone-salmeterol and Moxonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects: central sympatholytic action of moxonidine versus beta-2 agonist sympathetic stimulation; no pharmacokinetic interaction is known.
What to do
No dose change is generally required; monitor blood pressure and heart rate when starting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Moxonidine?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Moxonidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Moxonidine is a centrally acting antihypertensive that can cause drowsiness and lower blood pressure, whereas salmeterol can cause tachycardia and stimulation. The net effect is unpredictable and usually small.
How serious is the interaction between Fluticasone-salmeterol and Moxonidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor blood pressure and heart rate when starting either drug.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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