Drug interactions
Fluticasone-salmeterol + Ofatumumab sc
Severity: Minor
Fluticasone-salmeterol and Ofatumumab sc: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and inhaled fluticasone has corticosteroid immunosuppressive effects. Systemic exposure from inhaled fluticasone is low, so additive infection risk is expected to be small.
What this interaction means in plain words
Fluticasone-salmeterol and Ofatumumab sc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive immunosuppression, limited by the low systemic exposure to inhaled corticosteroid.
What to do
Continue inhaled therapy as indicated and monitor for infections, including oral candidiasis. Reassess if high-dose or additional systemic steroids are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Ofatumumab sc?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Ofatumumab sc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ofatumumab depletes B cells and inhaled fluticasone has corticosteroid immunosuppressive effects. Systemic exposure from inhaled fluticasone is low, so additive infection risk is expected to be small.
How serious is the interaction between Fluticasone-salmeterol and Ofatumumab sc?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue inhaled therapy as indicated and monitor for infections, including oral candidiasis. Reassess if high-dose or additional systemic steroids are used.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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