Drug interactions
Fluticasone-salmeterol + Opium tincture
Severity: Minor
Fluticasone-salmeterol and Opium tincture: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opium tincture causes sedation and respiratory depression, which may be dangerous in patients with obstructive lung disease. Salmeterol does not reverse these effects. The main concern is opioid-related respiratory depression in patients using inhalers for airway disease.
What this interaction means in plain words
Fluticasone-salmeterol and Opium tincture have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No true interaction; opioid central depression acts independently of beta-2 agonism.
What to do
Use the lowest effective opioid dose and monitor respiratory status in patients with asthma or COPD.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Opium tincture?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Opium tincture have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opium tincture causes sedation and respiratory depression, which may be dangerous in patients with obstructive lung disease. Salmeterol does not reverse these effects. The main concern is opioid-related respiratory depression in patients using inhalers for airway disease.
How serious is the interaction between Fluticasone-salmeterol and Opium tincture?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor respiratory status in patients with asthma or COPD.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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