Drug interactions
Fluticasone-salmeterol + Parecoxib
Severity: Minor
Fluticasone-salmeterol and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib may cause potassium retention through reduced renal prostaglandin effects, while salmeterol can lower potassium. These effects largely oppose each other and are rarely clinically significant.
What this interaction means in plain words
Fluticasone-salmeterol and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on serum potassium: NSAID-related renal retention versus beta-2 mediated intracellular shift.
What to do
No routine action is needed; check potassium if other risk factors for dyskalemia are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Parecoxib?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib may cause potassium retention through reduced renal prostaglandin effects, while salmeterol can lower potassium. These effects largely oppose each other and are rarely clinically significant.
How serious is the interaction between Fluticasone-salmeterol and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check potassium if other risk factors for dyskalemia are present.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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