Drug interactions
Fluticasone-salmeterol + Pentobarbital
Severity: Minor
Fluticasone-salmeterol and Pentobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital is a sedative barbiturate and a CYP3A4 inducer. It may lower fluticasone and salmeterol exposure modestly, while its sedative effect is not meaningfully offset by salmeterol.
What this interaction means in plain words
Fluticasone-salmeterol and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP3A4 may increase metabolism of fluticasone and salmeterol.
What to do
Monitor respiratory symptom control during prolonged barbiturate use and adjust inhaled therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Pentobarbital?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Pentobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pentobarbital is a sedative barbiturate and a CYP3A4 inducer. It may lower fluticasone and salmeterol exposure modestly, while its sedative effect is not meaningfully offset by salmeterol.
How serious is the interaction between Fluticasone-salmeterol and Pentobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptom control during prolonged barbiturate use and adjust inhaled therapy if control worsens.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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