Drug interactions
Fluticasone-salmeterol + Phenylephrine po
Severity: Minor
Fluticasone-salmeterol and Phenylephrine po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral phenylephrine is an alpha agonist decongestant with modest systemic effects. With salmeterol it may add to blood pressure elevation, tachycardia and nervousness, mainly in patients with cardiovascular disease.
What this interaction means in plain words
Fluticasone-salmeterol and Phenylephrine po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive adrenergic stimulation, with alpha-1 vasoconstriction from phenylephrine and beta agonism from salmeterol.
What to do
Monitor blood pressure and heart rate in hypertensive or cardiac patients, and avoid decongestants if these rise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Phenylephrine po?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Phenylephrine po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral phenylephrine is an alpha agonist decongestant with modest systemic effects. With salmeterol it may add to blood pressure elevation, tachycardia and nervousness, mainly in patients with cardiovascular disease.
How serious is the interaction between Fluticasone-salmeterol and Phenylephrine po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate in hypertensive or cardiac patients, and avoid decongestants if these rise.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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