Drug interactions
Fluticasone-salmeterol + Phenylephrine
Severity: Moderate
Fluticasone-salmeterol and Phenylephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol and phenylephrine both have sympathomimetic activity, so combined use may increase blood pressure, heart rate and palpitations. Patients with cardiovascular disease are most at risk.
What this interaction means in plain words
Fluticasone-salmeterol and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluticasone-salmeterol belongs to Respiratory; Phenylephrine belongs to Respiratory.
Why it happens
Additive adrenergic stimulation (beta-2 agonism plus alpha-1 agonism).
What to do
Monitor blood pressure and heart rate, and avoid oral decongestant use in patients with uncontrolled hypertension or arrhythmia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone-salmeterol and Phenylephrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Frequently asked questions
Can I take Fluticasone-salmeterol with Phenylephrine?
MediHelp rates the interaction as moderate. Fluticasone-salmeterol and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salmeterol and phenylephrine both have sympathomimetic activity, so combined use may increase blood pressure, heart rate and palpitations. Patients with cardiovascular disease are most at risk.
How serious is the interaction between Fluticasone-salmeterol and Phenylephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and avoid oral decongestant use in patients with uncontrolled hypertension or arrhythmia.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
