Drug interactions
Fluticasone-salmeterol + Pindolol
Severity: Major
Fluticasone-salmeterol and Pindolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol is a nonselective beta blocker with partial agonist activity that can blunt salmeterol's bronchodilation and trigger bronchospasm in susceptible patients. Patients with asthma are most at risk.
What this interaction means in plain words
Fluticasone-salmeterol and Pindolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors by a nonselective beta blocker.
What to do
Avoid pindolol in patients with asthma or significant bronchospastic disease; consider a cardioselective beta blocker or non-beta-blocker alternative with monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Pindolol?
MediHelp rates the interaction as major. Fluticasone-salmeterol and Pindolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pindolol is a nonselective beta blocker with partial agonist activity that can blunt salmeterol's bronchodilation and trigger bronchospasm in susceptible patients. Patients with asthma are most at risk.
How serious is the interaction between Fluticasone-salmeterol and Pindolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pindolol in patients with asthma or significant bronchospastic disease; consider a cardioselective beta blocker or non-beta-blocker alternative with monitoring.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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