Drug interactions
Fluticasone-salmeterol + Salicylates
Severity: Minor
Fluticasone-salmeterol and Salicylates: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salmeterol can lower serum potassium through beta-2 stimulation, and the added effect of non-aspirin salicylates on potassium is unclear. No clinically meaningful interaction is established at usual doses.
What this interaction means in plain words
Fluticasone-salmeterol and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
The mechanism is not established; salmeterol shifts potassium into cells, and any contribution of salicylates is uncertain.
What to do
No routine action is needed. Check potassium if the patient has other risks for hypokalemia or is taking high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Salicylates?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Salicylates have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salmeterol can lower serum potassium through beta-2 stimulation, and the added effect of non-aspirin salicylates on potassium is unclear. No clinically meaningful interaction is established at usual doses.
How serious is the interaction between Fluticasone-salmeterol and Salicylates?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Check potassium if the patient has other risks for hypokalemia or is taking high doses.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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