Drug interactions
Fluticasone-salmeterol + Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol
Severity: Minor
Fluticasone-salmeterol and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid and electrolyte losses, which can include hypokalemia, and salmeterol can further lower serum potassium. The combined effect is generally small, but it could matter in patients with cardiac disease or other QT risk factors.
What this interaction means in plain words
Fluticasone-salmeterol and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive lowering of serum potassium through gastrointestinal loss and beta-2 agonist-induced intracellular shift.
What to do
Ensure adequate hydration and check electrolytes in patients with cardiac disease or other risk factors. No routine change in inhaler use is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Frequently asked questions
Can I take Fluticasone-salmeterol with Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bowel preparations cause fluid and electrolyte losses, which can include hypokalemia, and salmeterol can further lower serum potassium. The combined effect is generally small, but it could matter in patients with cardiac disease or other QT risk factors.
How serious is the interaction between Fluticasone-salmeterol and Sodium sulfate / potassium chloride / magnesium sulfate / polyethylene glycol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check electrolytes in patients with cardiac disease or other risk factors. No routine change in inhaler use is needed.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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