Drug interactions
Fluticasone-salmeterol + Xylometazoline
Severity: Minor
Fluticasone-salmeterol and Xylometazoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xylometazoline is a topical nasal sympathomimetic with low systemic absorption at labeled doses. Additive cardiovascular effects with salmeterol are possible but unlikely to matter clinically.
What this interaction means in plain words
Fluticasone-salmeterol and Xylometazoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fluticasone-salmeterol belongs to Respiratory; Xylometazoline belongs to Respiratory.
Why it happens
Theoretical additive sympathomimetic effects at high systemic exposure.
What to do
No action needed at usual nasal doses; avoid prolonged or excessive use in patients with significant cardiovascular disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Frequently asked questions
Can I take Fluticasone-salmeterol with Xylometazoline?
MediHelp rates the interaction as minor. Fluticasone-salmeterol and Xylometazoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Xylometazoline is a topical nasal sympathomimetic with low systemic absorption at labeled doses. Additive cardiovascular effects with salmeterol are possible but unlikely to matter clinically.
How serious is the interaction between Fluticasone-salmeterol and Xylometazoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action needed at usual nasal doses; avoid prolonged or excessive use in patients with significant cardiovascular disease.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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