Drug interactions
Fluvastatin + Glibenclamide
Severity: Moderate
Fluvastatin and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvastatin can modestly raise glyburide exposure, which may strengthen its glucose-lowering effect and increase the chance of hypoglycemia. Both drugs are CYP2C9 substrates, and fluvastatin inhibits that enzyme. The effect is usually small.
What this interaction means in plain words
Fluvastatin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Glibenclamide belongs to Endocrine.
Why it happens
Fluvastatin inhibits CYP2C9, which reduces the metabolism of glyburide.
What to do
Monitor blood glucose when fluvastatin is started or stopped in a patient taking glyburide. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Fluvastatin with Glibenclamide?
MediHelp rates the interaction as moderate. Fluvastatin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvastatin can modestly raise glyburide exposure, which may strengthen its glucose-lowering effect and increase the chance of hypoglycemia. Both drugs are CYP2C9 substrates, and fluvastatin inhibits that enzyme. The effect is usually small.
How serious is the interaction between Fluvastatin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fluvastatin is started or stopped in a patient taking glyburide. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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