Drug interactions
Fluvastatin + Indinavir
Severity: Minor
Fluvastatin and Indinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir can inhibit OATP1B1, but fluvastatin is mainly cleared by CYP2C9, so a substantial rise in exposure is not expected. Any increase in myopathy risk is likely small.
What this interaction means in plain words
Fluvastatin and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of OATP1B1-mediated hepatic uptake by indinavir.
What to do
No routine dose change is needed. Counsel the patient to report muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Indinavir?
MediHelp rates the interaction as minor. Fluvastatin and Indinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indinavir can inhibit OATP1B1, but fluvastatin is mainly cleared by CYP2C9, so a substantial rise in exposure is not expected. Any increase in myopathy risk is likely small.
How serious is the interaction between Fluvastatin and Indinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Counsel the patient to report muscle pain or weakness.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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