Drug interactions
Fluvastatin + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Fluvastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paritaprevir inhibits hepatic uptake transporters and may increase fluvastatin concentrations. Higher statin exposure raises the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Fluvastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1/1B3 (and possibly BCRP) by paritaprevir increases systemic fluvastatin exposure.
What to do
Use the lowest effective fluvastatin dose, or temporarily withhold it during the antiviral course. Monitor for muscle pain, weakness or dark urine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Fluvastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paritaprevir inhibits hepatic uptake transporters and may increase fluvastatin concentrations. Higher statin exposure raises the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Fluvastatin and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fluvastatin dose, or temporarily withhold it during the antiviral course. Monitor for muscle pain, weakness or dark urine.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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