Drug interactions
Fluvastatin + Phenobarbital
Severity: Minor
Fluvastatin and Phenobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces hepatic enzymes including CYP2C9 and may lower fluvastatin concentrations, reducing lipid-lowering efficacy.
What this interaction means in plain words
Fluvastatin and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzyme induction increases CYP2C9-mediated fluvastatin clearance.
What to do
Check the lipid profile after starting or stopping phenobarbital and adjust the fluvastatin dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Phenobarbital?
MediHelp rates the interaction as minor. Fluvastatin and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital induces hepatic enzymes including CYP2C9 and may lower fluvastatin concentrations, reducing lipid-lowering efficacy.
How serious is the interaction between Fluvastatin and Phenobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the lipid profile after starting or stopping phenobarbital and adjust the fluvastatin dose as needed.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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