Drug interactions
Fluvastatin + Phenytoin
Severity: Moderate
Fluvastatin and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluvastatin can raise phenytoin concentrations slightly, while phenytoin may increase fluvastatin clearance. Both drugs are CYP2C9 substrates. Changes are usually small, but phenytoin has a narrow therapeutic range.
What this interaction means in plain words
Fluvastatin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Phenytoin belongs to Central Nervous System.
Why it happens
Competition for CYP2C9 metabolism, with possible phenytoin induction of statin clearance.
What to do
Monitor phenytoin levels and for signs of toxicity when fluvastatin is started or changed. Check the lipid response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Fluvastatin with Phenytoin?
MediHelp rates the interaction as moderate. Fluvastatin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluvastatin can raise phenytoin concentrations slightly, while phenytoin may increase fluvastatin clearance. Both drugs are CYP2C9 substrates. Changes are usually small, but phenytoin has a narrow therapeutic range.
How serious is the interaction between Fluvastatin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and for signs of toxicity when fluvastatin is started or changed. Check the lipid response.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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