Drug interactions
Fluvastatin + Ponatinib
Severity: Moderate
Fluvastatin and Ponatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits BCRP and possibly OATP transporters, which may raise fluvastatin levels. Ponatinib itself can cause hepatotoxicity and muscle-related effects, so the combination may add to the risk.
What this interaction means in plain words
Fluvastatin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fluvastatin belongs to Cardiovascular; Ponatinib belongs to Oncology.
Why it happens
Possible inhibition of BCRP and hepatic uptake transporters by ponatinib increasing fluvastatin exposure.
What to do
Monitor for myopathy symptoms and liver enzymes. Reduce the fluvastatin dose if muscle toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluvastatin and Ponatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Other interactions of Ponatinib
Frequently asked questions
Can I take Fluvastatin with Ponatinib?
MediHelp rates the interaction as moderate. Fluvastatin and Ponatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ponatinib inhibits BCRP and possibly OATP transporters, which may raise fluvastatin levels. Ponatinib itself can cause hepatotoxicity and muscle-related effects, so the combination may add to the risk.
How serious is the interaction between Fluvastatin and Ponatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myopathy symptoms and liver enzymes. Reduce the fluvastatin dose if muscle toxicity occurs.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
