Drug interactions
Fluvastatin + Rifampin
Severity: Moderate
Fluvastatin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin lowers fluvastatin exposure modestly by inducing metabolism, although single-dose rifampin can briefly inhibit hepatic uptake. The net clinical effect is usually reduced cholesterol-lowering rather than toxicity.
What this interaction means in plain words
Fluvastatin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Rifampin induces CYP2C9 and other enzymes, and can inhibit OATP1B1 acutely.
What to do
Check lipid response during and after rifampin therapy and increase the fluvastatin dose if needed. Watch for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Rifampin?
MediHelp rates the interaction as moderate. Fluvastatin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin lowers fluvastatin exposure modestly by inducing metabolism, although single-dose rifampin can briefly inhibit hepatic uptake. The net clinical effect is usually reduced cholesterol-lowering rather than toxicity.
How serious is the interaction between Fluvastatin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check lipid response during and after rifampin therapy and increase the fluvastatin dose if needed. Watch for muscle symptoms.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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