Drug interactions
Fluvastatin + Sacubitril / valsartan
Severity: Moderate
Fluvastatin and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sacubitrilat inhibits OATP1B1 and OATP1B3, and sacubitril/valsartan raised exposure of some statins in studies. Fluvastatin exposure may increase, with a theoretical rise in muscle toxicity.
What this interaction means in plain words
Fluvastatin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1/1B3 hepatic uptake by sacubitril and its active metabolite.
What to do
Monitor for muscle symptoms and consider the lowest effective statin dose. Check creatine kinase if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Fluvastatin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sacubitrilat inhibits OATP1B1 and OATP1B3, and sacubitril/valsartan raised exposure of some statins in studies. Fluvastatin exposure may increase, with a theoretical rise in muscle toxicity.
How serious is the interaction between Fluvastatin and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms and consider the lowest effective statin dose. Check creatine kinase if symptoms occur.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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