Drug interactions
Fluvastatin + Saquinavir
Severity: Moderate
Fluvastatin and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually given with ritonavir, may increase fluvastatin exposure via transporter inhibition. This could raise the risk of statin-related myopathy.
What this interaction means in plain words
Fluvastatin and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of fluvastatin.
What to do
Use the lowest effective fluvastatin dose and counsel patients to report muscle pain. Check creatine kinase if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Saquinavir?
MediHelp rates the interaction as moderate. Fluvastatin and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir, usually given with ritonavir, may increase fluvastatin exposure via transporter inhibition. This could raise the risk of statin-related myopathy.
How serious is the interaction between Fluvastatin and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective fluvastatin dose and counsel patients to report muscle pain. Check creatine kinase if symptoms develop.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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