Drug interactions
Fluvastatin + Sofosbuvir / velpatasvir
Severity: Moderate
Fluvastatin and Sofosbuvir / velpatasvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir inhibits OATP1B1, OATP1B3, OATP2B1 and BCRP, which can increase statin concentrations. Raised fluvastatin exposure may heighten the risk of myopathy.
What this interaction means in plain words
Fluvastatin and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits hepatic and intestinal uptake and efflux transporters, increasing fluvastatin exposure.
What to do
Monitor for muscle toxicity and use the lowest effective fluvastatin dose during treatment. Counsel patients to report muscle pain or dark urine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvastatin
- Cyclosporin + Fluvastatin Major
- Fluvastatin + Gemfibrozil Major
- Fluvastatin + Letermovir Major
- Fluvastatin + Red yeast rice Major
- Apalutamide + Fluvastatin Moderate
- Cholestyramine + Fluvastatin Moderate
Frequently asked questions
Can I take Fluvastatin with Sofosbuvir / velpatasvir?
MediHelp rates the interaction as moderate. Fluvastatin and Sofosbuvir / velpatasvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir inhibits OATP1B1, OATP1B3, OATP2B1 and BCRP, which can increase statin concentrations. Raised fluvastatin exposure may heighten the risk of myopathy.
How serious is the interaction between Fluvastatin and Sofosbuvir / velpatasvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle toxicity and use the lowest effective fluvastatin dose during treatment. Counsel patients to report muscle pain or dark urine.
What other medicines interact with Fluvastatin?
MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporin, Gemfibrozil, Letermovir. The full list is on the Fluvastatin page.
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